Phytostilbenes as agrochemicals: biosynthesis, bioactivity, metabolic engineering and biotechnology

Philippe Jeandet; Alessandro Vannozzi; Eduardo Sobarzo-Sánchez; Md. Sahab Uddin; Roque Bru; Ascension Martínez-Márquez; Christophe Clément; Sylvain Cordelier; Azadeh Manayi; Seyed Fazel Nabavi; Mahsa Rasekhian; Gaber El-Saber Batiha; Haroon Khan; Iwona Morkunas; Tarun Belwal; Jingjie Jiang; Mattheos Koffas; Seyed Mohammad Nabavi

doi:10.1039/D0NP00030B

Phytostilbenes as agrochemicals: biosynthesis, bioactivity, metabolic engineering and biotechnology†

Philippe Jeandet,

*^a Alessandro Vannozzi,^b Eduardo Sobarzo-Sánchez,^cd Md. Sahab Uddin,

^ef Roque Bru,^g Ascension Martínez-Márquez,^g Christophe Clément,^a Sylvain Cordelier,^a Azadeh Manayi,^h Seyed Fazel Nabavi,ⁱ Mahsa Rasekhian,^j Gaber El-Saber Batiha,^k Haroon Khan,

^l Iwona Morkunas,^m Tarun Belwal,ⁿ Jingjie Jiang,^o Mattheos Koffas^o and Seyed Mohammad Nabaviⁱ

Author affiliations

* Corresponding authors

^a Research Unit “Induced Resistance and Plant Bioprotection”, EA 4707, SFR Condorcet FR CNRS 3417, Faculty of Sciences, University of Reims Champagne-Ardenne, PO Box 1039, 51687 Reims Cedex 2, France
E-mail: philippe.jeandet@univ-reims.fr

^b Department of Agronomy, Food, Natural Resources, Animals, and Environment (DAFNAE), University of Padova, 35020 Legnaro, PD, Italy

^c Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, Campus Vida, 15782 Santiago de Compostela, Spain

^d Instituto de Investigación e Innovación en Salud, Facultad de Ciencias de la Salud, Universidad Central de Chile, Chile

^e Department of Pharmacy, Southeast University, Dhaka, Bangladesh

^f Neuroscience Research Network, Dhaka, Bangladesh

^g Plant Proteomics and Functional Genomics Group, Department of Agrochemistry and Biochemistry, Faculty of Science, University of Alicante, Alicante, Spain

^h Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, 1417614411 Tehran, Iran

ⁱ Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran 14359-16471, Iran

^j Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

^k Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Damanhour University, Damanhour, AlBeheira, Egypt

^l Department of Pharmacy, Faculty of Chemical and Life Sciences, Abdul Wali Khan University Mardan, Pakistan

^m Department of Plant Physiology, Poznań University of Life Sciences, Wołyńska 35, 60-637 Poznań, Poland

ⁿ Zhejiang University, College of Biosystems Engineering and Food Science, Key Laboratory of Agro-Products Postharvest Handling of Ministry of Agriculture and Rural Affairs, Zhejiang Key Laboratory for Agri-Food Processing, Hangzhou 310058, The People's Republic of China

^o Dorothy and Fred Chau '71 Constellation Professor, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Room 4005D, 110 8th Street, Troy, NY, USA

Abstract

Covering: 1976 to 2020.

Although constituting a limited chemical family, phytostilbenes represent an emblematic group of molecules among natural compounds. Ever since their discovery as antifungal compounds in plants and their ascribed role in human health and disease, phytostilbenes have never ceased to arouse interest for researchers, leading to a huge development of the literature in this field. Owing to this, the number of references to this class of compounds has reached the tens of thousands. The objective of this article is thus to offer an overview of the different aspects of these compounds through a large bibliography analysis of more than 500 articles. All the aspects regarding phytostilbenes will be covered including their chemistry and biochemistry, regulation of their biosynthesis, biological activities in plants, molecular engineering of stilbene pathways in plants and microbes as well as their biotechnological production by plant cell systems.

Graphical abstract: Phytostilbenes as agrochemicals: biosynthesis, bioactivity, metabolic engineering and biotechnology

Natural Product Reports

Phytostilbenes as agrochemicals: biosynthesis, bioactivity, metabolic engineering and biotechnology†

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