Stereoselective synthesis and applications of spirocyclic oxindoles
Alexander J.
Boddy 
a
and
James A.
Bull
*a
a
and
James A.
Bull
*a
Abstract
The development of novel synthetic strategies to form new chemical entities in a stereoselective manner is an ongoing significant objective in organic and medicinal chemistry. This review analyses the development of new stereoselective approaches to spirocyclic oxindoles with spiro-3- to 8-membered rings. It highlights the importance of these structures for applications in medicinal chemistry, as intermediates or final products in total synthesis and as model compounds for the development of enantioselective catalytic methodologies.
- This article is part of the themed collections: Recent Open Access Articles in Frontiers Journals and 2021 Organic Chemistry Frontiers Review-type Articles
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