Issue 50, 2021

Recent advances in acyl radical enabled reactions between aldehydes and alkenes

Abstract

Radical-mediated functionalization of alkenes has been emerging as an elegant and straightforward protocol to increase molecule complexity. Moreover, the abstraction of a hydrogen atom from aldehydes to afford acyl radicals has evolved as a rising star due to its high atom-economy and the ready availability of aldehydes. Considering the great influence and synthetic potential of acyl radical enabled reactions between aldehydes and alkenes, we provide a summary of the state of the art in this field with a specific emphasis on the working models and corresponding mechanisms. The discussion is divided according to the kind of alkenes and reaction type.

Graphical abstract: Recent advances in acyl radical enabled reactions between aldehydes and alkenes

Article information

Article type
Feature Article
Submitted
21 Apr 2021
Accepted
25 May 2021
First published
25 May 2021

Chem. Commun., 2021,57, 6111-6120

Recent advances in acyl radical enabled reactions between aldehydes and alkenes

Y. Liu, Y. Ouyang, H. Zheng, H. Liu and W. Wei, Chem. Commun., 2021, 57, 6111 DOI: 10.1039/D1CC02112E

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