SCHEDULED MAINTENANCE
Electrochemically enabled rhodium-catalyzed [4 + 2] annulations of arenes with alkynes†
Li-Rong
Wen 
*a
and
Lin-Bao
Zhang
*a
*a
and
Lin-Bao
Zhang
*a
Abstract
Herein, electrochemically driven, Rh(III)-catalyzed regioselective annulations of arenes with alkynes have been established. The strategy, combining the use of a rhodium catalyst with electricity, not only avoids the need for using a stoichiometric amount of external oxidant, but also ensures that the transformations proceed under mild and green conditions, which enable broad functional group compatibility with a variety of substrates, including drugs and pharmaceutical motifs. Moreover, the electrolysis reaction was made operationally simple by employing an undivided cell, and proceeds efficiently in aqueous solution in air.
![Graphical abstract: Electrochemically enabled rhodium-catalyzed [4 + 2] annulations of arenes with alkynes](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D1GC03187B&imageInfo.ImageIdentifier.Year=2021)
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