Issue 44, 2021

Lewis acid-catalyzed [3 + 2] annulations of oxindole based spirocyclic donor–acceptor cyclopropanes with ynamides

Abstract

[3 + 2] annulations of oxindole based spirocyclic donor–acceptor cyclopropanes and ynamides catalyzed by copper triflate have been developed for the synthesis of biologically important spirocyclopenteneoxindoles. These reactions tolerated a wide scope of substrates and provided the desired products in good to high yields (up to 90%) with up to >40 : 1 diastereoselectivities under mild conditions.

Graphical abstract: Lewis acid-catalyzed [3 + 2] annulations of oxindole based spirocyclic donor–acceptor cyclopropanes with ynamides

Supplementary files

Article information

Article type
Communication
Submitted
28 Sep 2021
Accepted
27 Oct 2021
First published
01 Nov 2021

Org. Biomol. Chem., 2021,19, 9645-9648

Lewis acid-catalyzed [3 + 2] annulations of oxindole based spirocyclic donor–acceptor cyclopropanes with ynamides

D. Zhang, Q. Cheng, L. Chen, H. Deng, H. Cai and Q. Zhang, Org. Biomol. Chem., 2021, 19, 9645 DOI: 10.1039/D1OB01922H

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