Issue 19, 2021
From the journal:

RSC Advances

α-Aminoazoles/azines: key reaction partners for multicomponent reactions

Shah Imtiaz,a   Jahangir Ahmad war,b   Syqa Banooc  and  Sarfaraz khan ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Aligarh Muslim University Aligarh, India-202002
E-mail: greatkhan91@gmail.com

b Department of Chemistry, National Institute of Technology, Kashmir, India-190006

c Department of Chemistry, Mangalayatan University, Beswan, Aligarh, India-202146

Abstract

Aromatic α-aminoazaheterocycles are the focus of significant investigations and exploration by researchers owing to their key role in diverse biological and physiological processes. The existence of their derivatives in numerous drugs and alkaloids is due to their heterocyclic nitrogenous nature. Therefore, the synthesis of a structurally diverse range of their derivatives through simple and convenient methods represents a vital field of synthetic organic chemistry. Multicomponent reactions (MCRs) provide a platform to introduce desirable structure diversity and complexity into a molecule in a single operation with a significant reduction in the use of harmful organic waste, and hence have attracted particular attention as an excellent tool to access these derivatives. This review covers the advances made from 2010 to the beginning of 2020 in terms of the utilization of α-aminoazaheterocycles as synthetic precursors in MCRs.

Graphical abstract: α-Aminoazoles/azines: key reaction partners for multicomponent reactions

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Article information

DOI
https://doi.org/10.1039/D1RA00392E
Article type
Review Article
Submitted
16 Jan 2021
Accepted
23 Feb 2021
First published
16 Mar 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 11083-11165

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α-Aminoazoles/azines: key reaction partners for multicomponent reactions

S. Imtiaz, J. Ahmad war, S. Banoo and S. khan, RSC Adv., 2021, 11, 11083 DOI: 10.1039/D1RA00392E

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