Issue 0, 1966
From the journal:

Journal of the Chemical Society C: Organic

Antibiotics of the ostreogrycin complex. Part II. Structure of ostreogrycin A

G. R. Delpierre,   F. W. Eastwood,   G. E. Gream,   D. G. I. Kingston,   P. S. Sarin,   Lord Todd  and  D. H. Williams  

Abstract

Structure (XXIII) is suggested for ostreogrycin A, an antibiotic produced by the soil organism Streptomyces ostreogriseus. Acid hydrolysis of “perhydro A,” prepared by complete hydrogenation of the antibiotic, yields inter alia 4,6-dimethyl-γ-heptanolactone, DL-alanine, proline, and 10-amino-7-methyl-δ-dec-2-enolactone. Ozonolysis of the antibiotic with oxidative working-up yields glycine and β-alanine, while reductive ozonolysis yields methyl glyoxal and 2,4-dimethylpent-2-enal. The production of small quantities of glycine and serine on hydrolysis of ostreogrycin A and its reduction products is explained by the presence of an oxazole ring system in the antibiotic.

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/J39660001653
Article type
Paper

J. Chem. Soc. C, 1966, 1653-1669

Permissions

Request permissions

Antibiotics of the ostreogrycin complex. Part II. Structure of ostreogrycin A

G. R. Delpierre, F. W. Eastwood, G. E. Gream, D. G. I. Kingston, P. S. Sarin, L. Todd and D. H. Williams, J. Chem. Soc. C, 1966, 1653 DOI: 10.1039/J39660001653

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements