Issue 8, 1969

Cobyric acid and related compounds from vitamin B12

Abstract

Under controlled conditions cobyric acid is obtained directly (10%) by the action of concentrated hydrochloric acid on vitamin B12. The hydrolysis is complicated not only by the expected formation of other corrinoids of the normal series, but also by the formation of a second series of compounds which are darker than the normal derivatives, and which are related to Factor Ia. Cobinamide and Factor Ia may conveniently be obtained by the action of trifluoroacetic acid upon vitamin B12.

Article information

Article type
Paper

J. Chem. Soc. C, 1969, 1163-1166

Cobyric acid and related compounds from vitamin B12

R. Bonnett, J. M. Godfrey and D. G. Redman, J. Chem. Soc. C, 1969, 1163 DOI: 10.1039/J39690001163

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