Issue 0, 1982

Indole β-nucleophilic substitution. Part 3. Synthesis of four isomeric pyrido[x′,y′:5,6]oxepino[3,2-b]indolones

Abstract

Condensations of 2-lithio-1-phenylsulphonylindole with the four pyridine analogues of phthalide gave 1-phenylsulphonylindol-2-yl o-hydroxymethylpyridyl ketones, from which on treatment with base were obtained the title compounds, by a process of intramolecular Indole β-nucleophilic substitution. This new aspect of Indole chemistry is discussed in the context of other related processes.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1982, 435-439

Indole β-nucleophilic substitution. Part 3. Synthesis of four isomeric pyrido[x′,y′:5,6]oxepino[3,2-b]indolones

M. G. Beal, W. R. Ashcroft, M. M. Cooper and J. A. Joule, J. Chem. Soc., Perkin Trans. 1, 1982, 435 DOI: 10.1039/P19820000435

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