Issue 0, 1984
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Triazines and related products. Part 26. Synthesis and chemistry of bicyclic analogues of the antitumour drug 2,4,6-tris(dimethylamino)-1,3,5-triazine (hexamethylmelamine)

Simon P. Langdon,   Richard J. Simmonds  and  Malcolm F. G. Stevens  

Abstract

Interaction of 2,4-bis(dimethylamino)-6-hydrazino-1,3,5-triazine (1c) with aryl aldehydes yields a series of aryl hydrazones (4) which cyclise to 3-aryl-5,7-bis(dimethylamino)-1,2,4-triazolo[4,3-a]-[1,3,5]triazines (6) with lead(IV) acetate in dichloromethane. Rearrangement of these bicycles in methanolic sodium hydroxide affords stable isomeric 2-aryl-5,7-bis(dimethylamino)[1,2,4]triazolo-[1,5-a][1,3,5]triazines (7). Selected examples from both series of triazolotriazines were screened against the mouse M5076 reticulum cell sarcoma and P388 leukaemia in vivo but proved to have no antitumour activity.

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/P19840000993
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1984, 993-998

Permissions

Request permissions

Triazines and related products. Part 26. Synthesis and chemistry of bicyclic analogues of the antitumour drug 2,4,6-tris(dimethylamino)-1,3,5-triazine (hexamethylmelamine)

S. P. Langdon, R. J. Simmonds and M. F. G. Stevens, J. Chem. Soc., Perkin Trans. 1, 1984, 993 DOI: 10.1039/P19840000993

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements