Issue 0, 1987
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Nucleoside phosphonates: part 7. Studies on the oxidation of nucleoside phosphonate esters

Per J. Garegg,   Tor Regberg,   Jacek Stawinski  and  Roger Strömberg  

Abstract

Oxidation of phosphonate mono- and di-esters with various oxidizing agents including diaryl disulphides, hexachloroacetone, and iodine, has been investigated under various reaction conditions. The most efficient oxidation procedure consists of treatment of phosphonate esters with iodine in pyridine–water. When the phosphonate esters were presilylated by treatment with trimethylsilyl chloride, the subsequent oxidation with aqueous iodine was faster. 31P N.m.r. spectroscopic studies have enabled us to propose the most likely pathway for the majority of the oxidations.

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Article information

DOI
https://doi.org/10.1039/P19870001269
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1987, 1269-1273

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Nucleoside phosphonates: part 7. Studies on the oxidation of nucleoside phosphonate esters

P. J. Garegg, T. Regberg, J. Stawinski and R. Strömberg, J. Chem. Soc., Perkin Trans. 1, 1987, 1269 DOI: 10.1039/P19870001269

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