Issue 21, 1996

Synthesis of neoflavones by Suzuki arylation of 4-substituted coumarins

Abstract

Palladium-catalysed coupling of the 4-chloro- or 4-bromo-coumarins 1–4 with arylboronic acids 5–13 under the Suzuki reaction conditions constitutes an efficient access to 4-arylcoumarins. These 4-arylcoumarins can also be obtained in good yields (70–97%) by treatment of 4-trifluoromethyl-sulfonyloxycoumarins 35–38 with arylboronic acids under modified Suzuki reaction conditions, involving the use of copper(I) iodide as a co-catalyst.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1996, 2591-2597

Synthesis of neoflavones by Suzuki arylation of 4-substituted coumarins

G. M. Boland, D. M. X. Donnelly, J. Finet and M. D. Rea, J. Chem. Soc., Perkin Trans. 1, 1996, 2591 DOI: 10.1039/P19960002591

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