Issue 1, 2007
From the journal:

Dalton Transactions

Rhenium diazenide ternary complexes with dithiocarbamate ligands: towards new rhenium radiopharmaceuticals

Andrew R. Cowley,a   Jonathan R. Dilworth,*b   Paul S. Donnellycd  and  Susan J. Rossb  

* Corresponding authors

a Chemical Crystallography, University of Oxford, 12 Mansfield Road, Oxford, U. K.

b Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, U. K.
E-mail: jon.dilworth@chem.ox.ac.uk
Fax: 01865-272690
Tel: 01865-285151

c School of Chemistry, University of Melbourne, Victoria, Australia
E-mail: pauld@unimelb.edu.au

d Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Victoria, Australia

Abstract

The reaction of the mono-diazenide core, [ReCl2(NNC6H4-4-OCH3)(NCCH3)(PPh3)2], with four equivalents of the sodium or potassium salts of dithiocarbamate (dtc) ligands gives neutral complexes of the formula [Re(NNC6H4-4-OCH3)(dtc)2(PPh3)]. It is possible to use a wide range of dithiocarbamate ligands (S2CNRR′) with a variety of R groups (R = R′ = methyl, phenyl or ethyl; R = methyl, R′ = phenyl and R = R′ = morpholino). Substitution reactions with dtc ligands on the mono-diazenide derived from 2-hydrazinopyridine, [ReCl2(NNC5H4N)(PPh3)2, give the analogous complexes, [Re(NNC6H5N)(dtc)2(PPh3)]. The new complexes have been characterised by a combination of NMR spectroscopy, mass spectrometry and X-ray crystallography. Cyclic voltammetry measurements in dimethyl formamide show that the rhenium diazenido-dtc complexes undergo a quasi-reversible oxidation tentatively assigned to a ReIII/ReIV oxidation. Since the parent complex, [ReCl2(NNC6H4-4-R)(NCCH3)(PPh3)2] can be prepared directly from perrhenate and readily derivatised with dtc ligands these complexes have potential relevance to the development of new therapeutic rhenium radiopharmaceuticals.

Graphical abstract: Rhenium diazenide ternary complexes with dithiocarbamate ligands: towards new rhenium radiopharmaceuticals

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Article information

DOI
https://doi.org/10.1039/B611403B
Article type
Paper
Submitted
10 Aug 2006
Accepted
09 Oct 2006
First published
31 Oct 2006

Dalton Trans., 2007, 73-82

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Rhenium diazenide ternary complexes with dithiocarbamate ligands: towards new rhenium radiopharmaceuticals

A. R. Cowley, J. R. Dilworth, P. S. Donnelly and S. J. Ross, Dalton Trans., 2007, 73 DOI: 10.1039/B611403B

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