Issue 7, 2007
From the journal:

Molecular BioSystems

Inhibition of lysine biosynthesis: an evolving antibiotic strategy

Craig A. Hutton,*ab   Matthew A. Peruginibc  and  Juliet A. Gerrardd  

* Corresponding authors

a School of Chemistry, The University of Melbourne, Parkville, Australia
E-mail: chutton@unimelb.edu.au
Fax: +61 3 9347 8124
Tel: +61 3 8344 2393

b Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Australia

c Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Australia.

d School of Biological Sciences, University of Canterbury, Christchurch, New Zealand

Abstract

Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel antibacterial agents as it provides lysine for protein synthesis and both lysine and meso-diaminopimelate for construction of the bacterial peptidoglycancell wall. In this Highlight article we review recent advances in the validation of antibiotic targets, studies of the enzymes of the lysine biosynthetic pathway and development of inhibitors of these enzymes.

Graphical abstract: Inhibition of lysine biosynthesis: an evolving antibiotic strategy

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Article information

DOI
https://doi.org/10.1039/B705624A
Article type
Highlight
First published
23 May 2007

Mol. BioSyst., 2007,3, 458-465

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Inhibition of lysine biosynthesis: an evolving antibiotic strategy

C. A. Hutton, M. A. Perugini and J. A. Gerrard, Mol. BioSyst., 2007, 3, 458 DOI: 10.1039/B705624A

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