Issue 5, 2008
From the journal:

Chemical Communications

Construction of macrocyclic thiodepsipeptides: synthesis of a nosiheptide ‘southern hemisphere’ model system†

Marc C. Kimbera  and  Christopher J. Moody*a  

* Corresponding authors

a School of Chemistry, University of Nottingham, University Park, Nottingham, UK
E-mail: c.j.moody@nottingham.ac.uk
Fax: +44 115 951 3564

Abstract

A 20-membered macrocyclic thiodepsipeptide has been synthesized as a model for the southern hemisphere of nosiheptide, the key steps being assembly of an acyclic precursor by amide coupling of indole and thiazole fragments followed by formation of the thiolactone in the macrocyclization step.

Graphical abstract: Construction of macrocyclic thiodepsipeptides: synthesis of a nosiheptide ‘southern hemisphere’ model system

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Article information

DOI
https://doi.org/10.1039/B715644H
Article type
Communication
Submitted
10 Oct 2007
Accepted
15 Nov 2007
First published
23 Nov 2007

Chem. Commun., 2008, 591-593

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Construction of macrocyclic thiodepsipeptides: synthesis of a nosiheptide ‘southern hemisphere’ model system

M. C. Kimber and C. J. Moody, Chem. Commun., 2008, 591 DOI: 10.1039/B715644H

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