Issue 23, 2008
From the journal:

Organic & Biomolecular Chemistry

Development of a method for the parallel synthesis and purification of N-substituted pantothenamides, known inhibitors of coenzyme A biosynthesis and utilization†

Marianne van Wyka  and  Erick Strauss*a  

* Corresponding authors

a Department of Biochemistry, Stellenbosch University, Matieland 7602, South Africa
E-mail: estrauss@sun.ac.za
Fax: +27 21 808 5863
Tel: +27 21 808 5866

Abstract

N -Substituted pantothenamides are a class of pantothenic acid analogues which have been shown to act as inhibitors of coenzyme A biosynthesis and utilization, especially by blocking fatty acid metabolism through formation of inactive acyl carrier proteins. To fully explore the chemical diversity and inhibitory potential of these analogues we have developed a simple method for the parallel synthesis and purification of any number of pantothenamides from a single precursor, and subsequently evaluated a small library of these compounds as inhibitors of bacterial growth to demonstrate the potential and utility of the method.

Graphical abstract: Development of a method for the parallel synthesis and purification of N-substituted pantothenamides, known inhibitors of coenzyme A biosynthesis and utilization

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Article information

DOI
https://doi.org/10.1039/B811086G
Article type
Paper
Submitted
30 Jun 2008
Accepted
29 Aug 2008
First published
17 Oct 2008

Org. Biomol. Chem., 2008,6, 4348-4355

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Development of a method for the parallel synthesis and purification of N-substituted pantothenamides, known inhibitors of coenzyme A biosynthesis and utilization

M. van Wyk and E. Strauss, Org. Biomol. Chem., 2008, 6, 4348 DOI: 10.1039/B811086G

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