Issue 5, 2010
From the journal:

Journal of Analytical Atomic Spectrometry

Quantification method for elemental bio-imaging by LA-ICP-MS using metal spiked PMMA films

Christine Austin,a   Dominic Hare,a   Tristan Rawling,a   Andrew M. McDonagha  and  Philip Doble*a  

* Corresponding authors

a Elemental Bio-imaging Facility, Department of Chemistry and Forensic Science, University of Technology Sydney, Sydney, NSW, Australia
E-mail: philip.doble@uts.edu.au
Fax: +61 2 9514 1460
Tel: +61 2 9514 1792

Abstract

A method for quantitative analysis of biological soft tissues by laser ablation-inductively coupled plasma-mass spectrometry has been developed. Polymer film standards were produced by spin coating spiked solutions of polymethylmethacrylate onto quartz substrates. Calibration curves throughout the range of 0–400 μg g−1 yielded correlation coefficients better than 0.999 for 66Zn and 63Cu. Spiked, homogenised soft tissue standards were quantified by LA-ICP-MS against the thin film standards. The results agreed with values calculated from solution nebulisation ICP-MS. A procedure for internal standardisation by employing ruthenium or yttrium in the underlying thin film was also assessed.

Graphical abstract: Quantification method for elemental bio-imaging by LA-ICP-MS using metal spiked PMMA films

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Article information

DOI
https://doi.org/10.1039/B911316A
Article type
Technical Note
Submitted
09 Jun 2009
Accepted
10 Dec 2009
First published
14 Jan 2010

J. Anal. At. Spectrom., 2010,25, 722-725

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Quantification method for elemental bio-imaging by LA-ICP-MS using metal spiked PMMA films

C. Austin, D. Hare, T. Rawling, A. M. McDonagh and P. Doble, J. Anal. At. Spectrom., 2010, 25, 722 DOI: 10.1039/B911316A

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