Issue 18, 2010
From the journal:

Chemical Communications

Developing an anion host for lipid A binding and antibacterial activity†

Luke C. Henderson,a   Jian Li,b   Roger L. Nation,b   Tony Velkovbc  and  Frederick M. Pfeffer*a  

* Corresponding authors

a School of Life and Environmental Sciences, Deakin University, Geelong, VIC, Australia
E-mail: fred.pfeffer@deakin.edu.au
Fax: +61 3 5227 1040
Tel: +61 3 5227 1439

b Monash Institute of Pharmaceutical Sciences, Parkville, VIC, Australia

c School of Medicine, Deakin University, Geelong, VIC, Australia

Abstract

New structural amphiphiles 2a and 2b bind the diphosphate lipid A anion and show potential as lead compounds for the development of novel antibacterial agents.

Graphical abstract: Developing an anion host for lipid A binding and antibacterial activity

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Article information

DOI
https://doi.org/10.1039/B925135A
Article type
Communication
Submitted
30 Nov 2009
Accepted
01 Mar 2010
First published
18 Mar 2010

Chem. Commun., 2010,46, 3197-3199

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Developing an anion host for lipid A binding and antibacterial activity

L. C. Henderson, J. Li, R. L. Nation, T. Velkov and F. M. Pfeffer, Chem. Commun., 2010, 46, 3197 DOI: 10.1039/B925135A

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