Issue 24, 2010
From the journal:

Chemical Communications

Low molecular weight MPEG-assisted organic synthesis†

Marek Figlus,a   Albert C. Tarruella,a   Anastasia Messer,a   Steven L. Sollisb  and  Richard C. Hartley*a  

* Corresponding authors

a WestCHEM Department of Chemistry, University of Glasgow, Glasgow, UK
E-mail: richh@chem.gla.ac.uk
Fax: +44 (0)141 3304888
Tel: +44 (0)141 3304398

b GSK Medicines Centre, Gunnels Wood Rd, Stevenage, UK

Abstract

A toolkit of low molecular weight MPEG-supported coupling agents (MIIDQ, MEDCI), reagents for the Mitsunobu reaction (MDEAD, MTPP), an alternative to diazomethane, and scavengers can be used in the solution-phase synthesis of amides, esters and ureas and are easily removed after use by solid-phase extraction (MSPE) using normal silica.

Graphical abstract: Low molecular weight MPEG-assisted organic synthesis

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Article information

DOI
https://doi.org/10.1039/C0CC00415D
Article type
Communication
Submitted
16 Mar 2010
Accepted
04 May 2010
First published
14 May 2010

Chem. Commun., 2010,46, 4405-4407

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Low molecular weight MPEG-assisted organic synthesis

M. Figlus, A. C. Tarruella, A. Messer, S. L. Sollis and R. C. Hartley, Chem. Commun., 2010, 46, 4405 DOI: 10.1039/C0CC00415D

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