Issue 6, 2011

Merely two mutations switch a DNA-hydrolyzing deoxyribozyme from heterobimetallic (Zn2+/Mn2+) to monometallic (Zn2+-only) behavior

Abstract

A deoxyribozyme that hydrolyzes DNA phosphodiester linkages with a requirement for both Zn2+ and Mn2+ is switched by only two nucleotide mutations to require Zn2+ alone, demonstrating that DNA-catalyzed DNA hydrolysis can be achieved using only one metal ion cofactor.

Graphical abstract: Merely two mutations switch a DNA-hydrolyzing deoxyribozyme from heterobimetallic (Zn2+/Mn2+) to monometallic (Zn2+-only) behavior

Supplementary files

Article information

Article type
Communication
Submitted
22 Oct 2010
Accepted
17 Nov 2010
First published
01 Dec 2010

Chem. Commun., 2011,47, 1749-1751

Merely two mutations switch a DNA-hydrolyzing deoxyribozyme from heterobimetallic (Zn2+/Mn2+) to monometallic (Zn2+-only) behavior

Y. Xiao, E. C. Allen and S. K. Silverman, Chem. Commun., 2011, 47, 1749 DOI: 10.1039/C0CC04575F

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