Issue 5, 2011
From the journal:

Dalton Transactions

The role of coordination chemistry in the development of copper and rhenium radiopharmaceuticals

Paul S. Donnelly*a  

* Corresponding authors

a The School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Melbourne, Australia

Abstract

There are several isotopes of copper and rhenium that are of interest in the development of new molecular imaging or radiotherapeutic agents. This perspective article highlights the role of coordination chemistry in the design of copper and rhenium radiopharmaceuticals engineered to selectively target tissue of interest such as cancer cells or pathological features associated with Alzheimer's disease. The coordination chemistry of copper bis(thiosemicarbazone) derivatives and copper macrocyclic complexes is discussed in terms of their potential application as targeted positron emission tomography tracers for non-invasive diagnostic imaging. A range of rhenium complexes with different ligands with rhenium in different oxidation states are introduced and their potential to be translated to new radiotherapeutic agents discussed.

Graphical abstract: The role of coordination chemistry in the development of copper and rhenium radiopharmaceuticals

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/C0DT01075H
Article type
Perspective
Submitted
20 Aug 2010
Accepted
09 Dec 2010
First published
04 Jan 2011

Dalton Trans., 2011,40, 999-1010

Permissions

Request permissions

The role of coordination chemistry in the development of copper and rhenium radiopharmaceuticals

P. S. Donnelly, Dalton Trans., 2011, 40, 999 DOI: 10.1039/C0DT01075H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements