Issue 23, 2011
From the journal:

Journal of Materials Chemistry

Tailored design of mechanically sensitive biocatalytic assemblies based on polyelectrolyte multilayers†

Damien Mertz,ab   Cédric Vogt,ab   Joseph Hemmerlé,ab   Christian Debry,c   Jean-Claude Voegel,ab   Pierre Schaafd  and  Philippe Lavalle*abc  

* Corresponding authors

a Institut National de la Santé et de la Recherche Médicale, INSERM Unité 977, 11 rue Humann, Strasbourg Cedex, France
E-mail: philippe.lavalle@inserm.fr
Fax: +33 3 68853379
Tel: +33 3 68 85 30 61

b Faculté de Chirurgie Dentaire, Université Louis Pasteur, 1 Place de l'Hôpital, Strasbourg, France

c Hôpitaux Universitaires de Strasbourg, 1 Place de l'Hôpital, Strasbourg, France

d Centre National de la Recherche Scientifique, UPR22, Institut Charles Sadron, 23 rue du Loess, BP 84047, Strasbourg, Cedex 2, France

Abstract

Mechanically sensitive surfaces responding to mechanical forces constitute an attractive emerging field of research. This requires the engineering of complex surfaces with finely controlled properties, especially regarding the permeability behaviour towards specific molecules. Here we designed such surfaces using polyelectrolyte multilayer nanostructures. Polylysine/hyaluronic acid multilayer films were used as a micro-container of enzymes and denser multilayers deposited on top of the reservoir were tailored to control their permeability. We find that permeability towards fluorescein diphosphate (FDP) not only depends on the number of bilayers constituting the barrier but more surprisingly on the deposition time of the polyelectrolytes during the barrier buildup, a long contact time (10 min) leading to porous barriers. This effect is explained by diffusion and exchange processes taking place in the reservoir during the buildup process. For films composed of a non-permeable barrier towards enzymatic substrate FDP, we tested the enzymatic activity when mechanical stretching was applied to the architecture. Under stretch and in the presence of FDP on top of the film, the catalytic activity was switched on. These biologically inspired surfaces constitute a first step to the development of novel platforms able to trigger and to modulate chemical reactions under a mechanical stimulus.

Graphical abstract: Tailored design of mechanically sensitive biocatalytic assemblies based on polyelectrolyte multilayers

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Article information

DOI
https://doi.org/10.1039/C0JM03496G
Article type
Paper
Submitted
16 Oct 2010
Accepted
02 Dec 2010
First published
10 Jan 2011

J. Mater. Chem., 2011,21, 8324-8331

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Tailored design of mechanically sensitive biocatalytic assemblies based on polyelectrolyte multilayers

D. Mertz, C. Vogt, J. Hemmerlé, C. Debry, J. Voegel, P. Schaaf and P. Lavalle, J. Mater. Chem., 2011, 21, 8324 DOI: 10.1039/C0JM03496G

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