Mevalonic acid lactone and the chemically synthesized all-trans-geranylfarnesyl pyrophosphate are converted into a tricyclic sesterterpene alcohol, ophiobolin F, by incubation with 100,000 ×g supernatant fraction from cell-free system of Chochlibolus heterostrophus.
S. Nozoe and M. Morisaki, J. Chem. Soc. D, 1969, 1319 DOI: 10.1039/C29690001319
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