Issue 38, 2012
From the journal:

Dalton Transactions

Remarkable in vitro bactericidal activity of bismuth(iii) sulfonates against Helicobacter pylori†

Philip C. Andrews,*a   Madleen Busse,a   Glen B. Deacon,a   Richard L. Ferrero,b   Peter C. Junk,‡a   Jonathan G. MacLellanc  and  Amelia Voma  

* Corresponding authors

a School of Chemistry, Monash University, Melbourne, VIC 3800, Australia
E-mail: phil.andrews@monash.edu
Fax: +61 3 9905 4597
Tel: +61 3 9905 5509

b Monash Institute of Medical Research, Centre of Innate Immunity and Infectious Diseases, Monash University, Melbourne, Australia

c Emerald Secondary College, 425 Belgrave-Gembrook Road, Emerald, Victoria 3782, Australia

Abstract

Four new tris-substituted bismuth(III) sulfonates of general formula [Bi(O3SR)3] (R = phenyl 1, p-tolyl 2, 2,4,6-mesityl 3 and S-(+)-10-camphoryl 4) have been synthesised and characterised. Their synthesis by solvent-free (SF) and solvent-mediated (SM) methods has been explored and their activity against Helicobacter pylori has been investigated. The compounds 1–4 display a remarkable in vitro activity against three laboratory strains of H. pylori (B128, 26 695 and 251) with minimum inhibitory concentration (MIC) values as low as 0.049 μg mL−1 for the strains B128 and 26 695, and 0.781 μg mL−1 for the clinical isolate 251. This places most MIC values in the nano-molar region and demonstrates the strong influence of the sulfonate group on the bactericidal properties. The novel solid state structure [Bi8(O3SMes)20(SO4)2(H2O)6]·(C7H8)75·(C777H888)777, derived from the SM reaction under reflux conditions, is presented and the incorporation of the two inorganic sulfate anions in the centre of the wheel-like bismuth sulfonate cluster explained.

Graphical abstract: Remarkable in vitro bactericidal activity of bismuth(iii) sulfonates against Helicobacter pylori

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2DT31360J
Article type
Paper
Submitted
26 Jun 2012
Accepted
25 Jul 2012
First published
25 Jul 2012

Dalton Trans., 2012,41, 11798-11806

Permissions

Request permissions

Remarkable in vitro bactericidal activity of bismuth(III) sulfonates against Helicobacter pylori

P. C. Andrews, M. Busse, G. B. Deacon, R. L. Ferrero, P. C. Junk, J. G. MacLellan and A. Vom, Dalton Trans., 2012, 41, 11798 DOI: 10.1039/C2DT31360J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements