Issue 24, 2012

PTSA-catalyzed Mannich-type–cyclization–oxidation tandem reactions: one-pot synthesis of 1,3,5-substituted pyrazoles from aldehydes, hydrazines and alkynes

Abstract

A convenient one-pot Mannich-type–cyclization–oxidation tandem process has been developed for the synthesis of 1,3,5-trisubstituted pyrazoles derivatives from aldehydes, hydrazines and alkynes using p-toluenesulfonic acid monohydrate (PTSA) as a multifunctional catalyst. This method provides a flexible and rapid route to 1,3,5-trisubstituted pyrazoles.

Graphical abstract: PTSA-catalyzed Mannich-type–cyclization–oxidation tandem reactions: one-pot synthesis of 1,3,5-substituted pyrazoles from aldehydes, hydrazines and alkynes

Supplementary files

Article information

Article type
Communication
Submitted
06 Mar 2012
Accepted
06 May 2012
First published
08 May 2012

Org. Biomol. Chem., 2012,10, 4696-4698

PTSA-catalyzed Mannich-type–cyclization–oxidation tandem reactions: one-pot synthesis of 1,3,5-substituted pyrazoles from aldehydes, hydrazines and alkynes

P. Liu, Y. Pan, Y. Xu and H. Wang, Org. Biomol. Chem., 2012, 10, 4696 DOI: 10.1039/C2OB25487E

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