Issue 14, 1980
From the journal:

Journal of the Chemical Society, Chemical Communications

4-Methoxy-2,6-dimethylbenzenesulphonyl (Mds): a new protecting group of the guanidino function in peptide synthesis

Masahiko Fujino,   Osamu Nishimura,   Mitsuhiro Wakimasu  and  Chieko Kitada  

Abstract

The 4-methoxy-2,6-dimethylbenzenesulphonyl (Mds) group for the protectiono of the guanidino function, which is readily removed with trifluoroacetic acid–thioanisole but is resistant to hydrogenolysis or treatment with dilute hydrogen chloride, can be used in the solution synthesis of arginine-containing peptides; this protecting group was effectively used in the synthesis of substance P and two LH–RH analogues.

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Article information

DOI
https://doi.org/10.1039/C39800000668
Article type
Paper

J. Chem. Soc., Chem. Commun., 1980, 668-669

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4-Methoxy-2,6-dimethylbenzenesulphonyl (Mds): a new protecting group of the guanidino function in peptide synthesis

M. Fujino, O. Nishimura, M. Wakimasu and C. Kitada, J. Chem. Soc., Chem. Commun., 1980, 668 DOI: 10.1039/C39800000668

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