The first total synthesis of Methanobacterium redox coenzyme Factor 420 (F420) has been achieved by the formation of a phosphotriester bond between a protected 10-D-ribityl-8-hydroxy-5-deazaisoalloxazine moiety and a peptide moiety, (L-lactate-γ-L-glutamyl)-L-glutamic acid tribenzyl ester, by the phosphite triester approach using β,β,β-trichloroethyl phosphorodichloridite, followed by successive deprotection.
K. Tanaka, T. Kimachi, M. Kawase and F. Yoneda, J. Chem. Soc., Chem. Commun., 1988, 524 DOI: 10.1039/C39880000524
To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.
If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.
If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.
Read more about how to correctly acknowledge RSC content.
Please wait while we load your content...