Issue 59, 2013
From the journal:

Chemical Communications

The core-inversible micelles for hydrophilic drug delivery†

Wenzhe Huang,a   Changying Shi,a   Yu Shao,a   Kit S. Lamb  and  Juntao Luo*a  

* Corresponding authors

a Department of Pharmacology, SUNY Upstate Cancer Research Institute, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
E-mail: luoj@upstate.edu
Fax: +1-315-464-5143
Tel: +1-315-464-7965

b Department of Biochemistry and Molecular Medicine, Division of Hematology and Oncology, Department of Internal Medicine, University of California Davis, Sacramento, CA 95817, USA

Abstract

A unique core-inversible micelle (CIM) was formed via PEG5kCA8 for hydrophilic drug delivery. An amyloid-fibril-inhibiting water-soluble molecule, congo red (CR), has been loaded into the hydrophilic core of CIMs. The targeting folate-CIMs significantly enhanced the intracellular delivery of hydrophilic CR in a folate receptor-expressing cell line.

Graphical abstract: The core-inversible micelles for hydrophilic drug delivery

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Article information

DOI
https://doi.org/10.1039/C3CC43209B
Article type
Communication
Submitted
01 May 2013
Accepted
31 May 2013
First published
31 May 2013

Chem. Commun., 2013,49, 6674-6676

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The core-inversible micelles for hydrophilic drug delivery

W. Huang, C. Shi, Y. Shao, K. S. Lam and J. Luo, Chem. Commun., 2013, 49, 6674 DOI: 10.1039/C3CC43209B

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