Issue 78, 2014
From the journal:

Chemical Communications

Counteracting the inhibitory effect of proteins towards lung surfactant substitutes: a fluorocarbon gas helps displace albumin at the air/water interface†

Phuc Nghia Nguyen,a   Mariam Veschgini,b   Motomu Tanaka,b   Gilles Waton,a   Thierry Vandammec  and  Marie Pierre Krafft*a  

* Corresponding authors

a Systèmes Organisés Fluorés à Finalités Thérapeutiques (SOFFT), Institut Charles Sadron (ICS) CNRS, Université de Strasbourg (UPR 22), 23 rue du Loess, 67034 Strasbourg Cedex 2, France
E-mail: krafft@unistra.fr

b Physical Chemistry of Biosystems, Institute of Physical Chemistry, University of Heidelberg, Im Neuenheimer Feld 253, 69120 Heidelberg, Germany

c Laboratoire de Conception et Application de Molécules Bioactives (CNRS UMR 7199), Université de Strasbourg, 74 route du Rhin, 67401 Illkirch Cedex, France

Abstract

Perfluorohexane gas lowers the kinetic barrier that opposes the displacement of albumin by dipalmitoylphosphatidylcholine at the air/water interface submitted to sinusoidal oscillations at frequencies in the range of those encountered in respiration.

Graphical abstract: Counteracting the inhibitory effect of proteins towards lung surfactant substitutes: a fluorocarbon gas helps displace albumin at the air/water interface

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Article information

DOI
https://doi.org/10.1039/C3CC47840H
Article type
Communication
Submitted
11 Oct 2013
Accepted
13 Aug 2014
First published
13 Aug 2014

Chem. Commun., 2014,50, 11576-11579

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Counteracting the inhibitory effect of proteins towards lung surfactant substitutes: a fluorocarbon gas helps displace albumin at the air/water interface

P. N. Nguyen, M. Veschgini, M. Tanaka, G. Waton, T. Vandamme and M. P. Krafft, Chem. Commun., 2014, 50, 11576 DOI: 10.1039/C3CC47840H

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