Issue 6, 2013
From the journal:

MedChemComm

Design and synthesis of β-amino alcohol based β-lactam–isatin chimeras and preliminary analysis of in vitro activity against the protozoal pathogen Trichomonas vaginalis†

Nisha,a   Vishu Mehra,a   Melissa Hopper,b   Neal Patel,b   Dominique Hall,b   Lisa A. Wrischnik,b   Kirkwood M. Landb  and  Vipan Kumar*a  

* Corresponding authors

a Department of Chemistry, Guru Nanak Dev University, Amritsar-143005, Punjab, India
E-mail: vipan_org@yahoo.com
Fax: +91-183-2258819-20
Tel: +91-183-2258802 ext. 3320

b Department of Biological Sciences, University of the Pacific, Stockton, CA 95211, USA

Abstract

We have described the synthesis of β-amino alcohol based β-lactam–isatin chimeras along with their in vitro evaluation against T. vaginalis. SAR studies showed dependence of activity on concentration as well as substituent on N-1 of β-lactam and C-5 of isatin with preference for a chloro-substituent for good activity.

Graphical abstract: Design and synthesis of β-amino alcohol based β-lactam–isatin chimeras and preliminary analysis of in vitro activity against the protozoal pathogen Trichomonas vaginalis

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Article information

DOI
https://doi.org/10.1039/C3MD00057E
Article type
Concise Article
Submitted
19 Feb 2013
Accepted
09 Apr 2013
First published
16 Apr 2013

Med. Chem. Commun., 2013,4, 1018-1024

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Design and synthesis of β-amino alcohol based β-lactam–isatin chimeras and preliminary analysis of in vitro activity against the protozoal pathogen Trichomonas vaginalis

Nisha, V. Mehra, M. Hopper, N. Patel, D. Hall, L. A. Wrischnik, K. M. Land and V. Kumar, Med. Chem. Commun., 2013, 4, 1018 DOI: 10.1039/C3MD00057E

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