Issue 19, 2013
From the journal:

RSC Advances

Mild and convenient one-pot synthesis of 2-amino-1,3,4-thiadiazoles using trimethylsilyl isothiocyanate (TMSNCS)†

Dinneswara Reddy Guda,a   Hyeon Mo Choa  and  Myong Euy Lee*a  

* Corresponding authors

a Department of Chemistry & Medical Chemistry, College of Science and Technology, Research & Education Center for Advanced Silicon Materials, Yonsei University, Wonju, Gangwon-do 220-710, South Korea
E-mail: melgg@yonsei.ac.kr
Fax: + 82-33-760-2182
Tel: + 82-33-760-2237

Abstract

A novel and efficient one-pot method has been developed for the synthesis of 2-amino-1,3,4-thiadiazoles using various carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS). In situ preparation of various thiosemicarbazides by the reaction of different carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS), followed by cyclodehydration of thiosemicarbazides under acidic conditions gave 2-amino-1,3,4-thiadiazoles in high yields (71–87%).

Graphical abstract: Mild and convenient one-pot synthesis of 2-amino-1,3,4-thiadiazoles using trimethylsilyl isothiocyanate (TMSNCS)

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Article information

DOI
https://doi.org/10.1039/C3RA00159H
Article type
Communication
Submitted
11 Jan 2013
Accepted
28 Feb 2013
First published
01 Mar 2013

RSC Adv., 2013,3, 6813-6816

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Mild and convenient one-pot synthesis of 2-amino-1,3,4-thiadiazoles using trimethylsilyl isothiocyanate (TMSNCS)

D. R. Guda, H. M. Cho and M. E. Lee, RSC Adv., 2013, 3, 6813 DOI: 10.1039/C3RA00159H

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