Issue 11, 2014

Fast detection of paracetamol on a gold nanoparticle–chitosan substrate by SERS

Abstract

A fast method for detecting pharmaceutical drugs, such as paracetamol, by surface-enhanced Raman spectroscopy (SERS) using a gold nanoparticle substrate was studied. Gold nanoparticles were synthesized using chitosan (AuNP–chitosan) as a reductant and capping agent and subsequently deposited on glass slides as a thin film. The SERS performance of AuNP–chitosan films was evaluated using methylene blue (MB, 10−6 mol L−1) as a SERS probe molecule. The method is based on drop-drying an analyte solution (paracetamol, 10−3 mol L−1) onto a substrate surface and subsequently analyzing by Raman spectroscopy. The spectra were obtained in 10 seconds with two accumulations and exhibit a high signal-to-noise ratio. This preliminary study supports the AuNP–chitosan substrate as a SERS sensor, for a convenient analytical method for detection of paracetamol and other pharmaceutical drug molecules.

Graphical abstract: Fast detection of paracetamol on a gold nanoparticle–chitosan substrate by SERS

Article information

Article type
Communication
Submitted
13 Mar 2014
Accepted
25 Mar 2014
First published
26 Mar 2014

Anal. Methods, 2014,6, 3564-3568

Author version available

Fast detection of paracetamol on a gold nanoparticle–chitosan substrate by SERS

E. D. B. Santos, E. C. N. L. Lima, C. S. D. Oliveira, F. A. Sigoli and I. O. Mazali, Anal. Methods, 2014, 6, 3564 DOI: 10.1039/C4AY00635F

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