Issue 13, 2014
From the journal:

Nanoscale

In vitro dosimetry of agglomerates†

V. Hirsch,‡a   C. Kinnear,‡a   L. Rodriguez-Lorenzo,‡a   C. A. Monnier,a   B. Rothen-Rutishauser,a   S. Baloga  and  A. Petri-Fink*ab  

* Corresponding authors

a Adolphe Merkle Institute, University of Fribourg, Route de l'Ancienne Papeterie, P.O. Box 209, Marly 1723, Switzerland

b Department of Chemistry, University of Fribourg, Fribourg 1700, Switzerland
E-mail: alke.fink@unifr.ch

Abstract

Agglomeration of nanoparticles in biological fluids is a pervasive phenomenon that leads to difficulty in the interpretation of results from in vitro exposure, primarily due to differing particokinetics of agglomerates to nanoparticles. Therefore, well-defined small agglomerates were designed that possessed different particokinetic profiles, and their cellular uptake was compared to a computational model of dosimetry. The approach used here paves the way for a better understanding of the impact of agglomeration on the nanoparticle–cell interaction.

Graphical abstract: In vitro dosimetry of agglomerates

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Article information

DOI
https://doi.org/10.1039/C4NR00460D
Article type
Paper
Submitted
23 Jan 2014
Accepted
17 Apr 2014
First published
21 Apr 2014

Nanoscale, 2014,6, 7325-7331

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In vitro dosimetry of agglomerates

V. Hirsch, C. Kinnear, L. Rodriguez-Lorenzo, C. A. Monnier, B. Rothen-Rutishauser, S. Balog and A. Petri-Fink, Nanoscale, 2014, 6, 7325 DOI: 10.1039/C4NR00460D

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