Issue 20, 2014

Templated assembly of albumin-based nanoparticles for simultaneous gene silencing and magnetic resonance imaging

Abstract

In this article, we address the design of innovative human serum albumin (HSA)-based nanoparticles loaded with silencing RNA and grafted with gadolinium complexes having average sizes ranging from ca. 50 to 150 nm according to the siRNA/HSA composition. The non-covalent siRNA/HSA assembly is formed on isobutyramide-modified mesoporous silica and the self-supported HSA-based nanoparticles are obtained following the silica template dissolution. These original protein particles provide simultaneous magnetic resonance imaging contrast enhancement and cellular in vitro gene silencing.

Graphical abstract: Templated assembly of albumin-based nanoparticles for simultaneous gene silencing and magnetic resonance imaging

Supplementary files

Article information

Article type
Communication
Submitted
13 May 2014
Accepted
28 Jul 2014
First published
05 Aug 2014

Nanoscale, 2014,6, 11676-11680

Author version available

Templated assembly of albumin-based nanoparticles for simultaneous gene silencing and magnetic resonance imaging

D. Mertz, C. Affolter-Zbaraszczuk, J. Barthès, J. Cui, F. Caruso, T. F. Baumert, J. Voegel, J. Ogier and F. Meyer, Nanoscale, 2014, 6, 11676 DOI: 10.1039/C4NR02623C

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