Issue 30, 2014
From the journal:

Organic & Biomolecular Chemistry

Synthesis of quinazolines via CuO nanoparticles catalyzed aerobic oxidative coupling of aromatic alcohols and amidines†

Wu Zhang,*a   Fei Guo,a   Fei Wang,a   Na Zhao,a   Liang Liu,a   Jia Lia  and  Zhenghua Wanga  

* Corresponding authors

a Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, People's Republic of China
E-mail: zhangwu@mail.ahnu.edu.cn
Fax: +86-553-3869310
Tel: +86-553-3883513

Abstract

CuO nanoparticles were found to be efficient catalysts for the synthesis of quinazoline derivatives; twenty-four products were obtained with good to excellent yields via reaction of N-arylamidines and aromatic aldehydes or benzyl alcohol in air. Neither a base nor an organic oxidant was necessary, and CuO nanoparticles can be recycled without a significant decrease in catalytic activity.

Graphical abstract: Synthesis of quinazolines via CuO nanoparticles catalyzed aerobic oxidative coupling of aromatic alcohols and amidines

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Article information

DOI
https://doi.org/10.1039/C4OB00569D
Article type
Paper
Submitted
15 Mar 2014
Accepted
12 Jun 2014
First published
12 Jun 2014

Org. Biomol. Chem., 2014,12, 5752-5756

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Synthesis of quinazolines via CuO nanoparticles catalyzed aerobic oxidative coupling of aromatic alcohols and amidines

W. Zhang, F. Guo, F. Wang, N. Zhao, L. Liu, J. Li and Z. Wang, Org. Biomol. Chem., 2014, 12, 5752 DOI: 10.1039/C4OB00569D

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