Issue 26, 2015
From the journal:

Chemical Communications

A new biomimetic route to engineer enzymatically active mechano-responsive materials†

César Rios,‡a   Johan Longo,‡a   Sarah Zahouani,bc   Tony Garnier,a   Cédric Vogt,bc   Andreas Reisch,d   Bernard Senger,bc   Fouzia Boulmedais,aef   Joseph Hemmerlé,bc   Karim Benmlih,bc   Benoît Frisch,d   Pierre Schaaf,*abcegh   Loïc Jierryaefg  and  Philippe Lavallebc  

* Corresponding authors

a ICS (UPR22-CNRS), 23 rue du Loess, Strasbourg, France
E-mail: schaaf@unistra.fr

b INSERM, UMR-S 1121, 11 rue Humann, 67085 Strasbourg Cedex, France

c Faculté de Chirurgie Dentaire, 8 rue Sainte Elisabeth, 67000 Strasbourg, France

d Laboratoire de Conception et Application de Molécules Bioactives, UMR 7199 CNRS, Université de Strasbourg, 67400 Illkirch, France

e icFRC, 8, allée Gaspard Monge, Strasbourg, France

f USIAS, 5 allée du Général Rouvillois, 67083 Strasbourg, France

g ECPM, 25 rue Becquerel, 67087 Strasbourg Cedex 2, France

h IUF, 103 Bd Saint-Michel, 75005 Paris, France

Abstract

Using modified β-galactosidase covalently linked to cross-linked polyelectrolyte multilayers (PEM), catalytically active materials have been designed. Their enzymatic activity can be modulated, partially in a reversible way, simply by stretching. This strategy, based on enzyme conformational changes, constitutes a new tool for the development of biocatalytic mechano-responsive materials.

Graphical abstract: A new biomimetic route to engineer enzymatically active mechano-responsive materials

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Article information

DOI
https://doi.org/10.1039/C5CC00329F
Article type
Communication
Submitted
13 Jan 2015
Accepted
13 Feb 2015
First published
19 Feb 2015

Chem. Commun., 2015,51, 5622-5625

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A new biomimetic route to engineer enzymatically active mechano-responsive materials

C. Rios, J. Longo, S. Zahouani, T. Garnier, C. Vogt, A. Reisch, B. Senger, F. Boulmedais, J. Hemmerlé, K. Benmlih, B. Frisch, P. Schaaf, L. Jierry and P. Lavalle, Chem. Commun., 2015, 51, 5622 DOI: 10.1039/C5CC00329F

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