Issue 38, 2015
From the journal:

Chemical Communications

Inhibited fragmentation of mAbs in buffered ionic liquids†

Romiza R. Mazid,a   R. Vijayaraghavan,c   Douglas R. MacFarlane,c   Christina Cortez-Jugob  and  Wenlong Cheng*a  

* Corresponding authors

a Department of Chemical Engineering, Monash University, Clayton 3800, VIC, Australia
E-mail: wenlong.cheng@monash.edu

b School of Chemistry, Monash University, Clayton 3800, VIC, Australia

c Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, VIC, Australia

Abstract

We thoroughly investigated the biological, structural and chemical stability of epidermal growth factor receptor monoclonal antibody (EGFR mAb) using choline-based buffered ionic liquids (BILs). The results demonstrated substantially enhanced stabilities in our BILs, indicating their huge promise as real-world green biological buffers for antibody storage and transportation.

Graphical abstract: Inhibited fragmentation of mAbs in buffered ionic liquids

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Article information

DOI
https://doi.org/10.1039/C5CC01877C
Article type
Communication
Submitted
05 Mar 2015
Accepted
02 Apr 2015
First published
02 Apr 2015

Chem. Commun., 2015,51, 8089-8092

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Inhibited fragmentation of mAbs in buffered ionic liquids

R. R. Mazid, R. Vijayaraghavan, D. R. MacFarlane, C. Cortez-Jugo and W. Cheng, Chem. Commun., 2015, 51, 8089 DOI: 10.1039/C5CC01877C

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