Issue 37, 2015

A fluorescent histone deacetylase (HDAC) inhibitor for cellular imaging

Abstract

Fluorescence microscopy studies using 4-morpholinoscriptaid (4MS) demonstrated rapid cellular uptake of this scriptaid analogue into the cytoplasm but no nuclear penetration. As 4MS and scriptaid have the same in vitro activity against HDACs and KASUMI-1 cells; 4MS exemplifies a rational approach to subtly modify ‘profluorogenic’ substrates for intracellular studies.

Graphical abstract: A fluorescent histone deacetylase (HDAC) inhibitor for cellular imaging

Supplementary files

Article information

Article type
Communication
Submitted
11 Mar 2015
Accepted
02 Apr 2015
First published
02 Apr 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 7827-7830

Author version available

A fluorescent histone deacetylase (HDAC) inhibitor for cellular imaging

C. L. Fleming, T. D. Ashton, C. Nowell, M. Devlin, A. Natoli, J. Schreuders and F. M. Pfeffer, Chem. Commun., 2015, 51, 7827 DOI: 10.1039/C5CC02059J

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