Issue 72, 2015
From the journal:

Chemical Communications

A fluorescent G-quadruplex probe for the assay of base excision repair enzyme activity†

Chang Yeol Lee,a   Ki Soo Parka  and  Hyun Gyu Park*a  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering (BK21 + Program), Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea
E-mail: hgpark@kaist.ac.kr
Fax: +82-42-350-3910
Tel: +82-42-350-3932

Abstract

A sensitive and selective assay of uracil DNA glycosylase (UDG) activity is developed by utilizing a G-quadruplex probe incorporating 2-aminopurine (2-AP), based on a novel design that excision reaction promoted by UDG triggers the formation of G-quadruplex structure with significant fluorescence enhancement of 2-AP within the probe.

Graphical abstract: A fluorescent G-quadruplex probe for the assay of base excision repair enzyme activity

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Article information

DOI
https://doi.org/10.1039/C5CC05010C
Article type
Communication
Submitted
17 Jun 2015
Accepted
20 Jul 2015
First published
20 Jul 2015

Chem. Commun., 2015,51, 13744-13747

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A fluorescent G-quadruplex probe for the assay of base excision repair enzyme activity

C. Y. Lee, K. S. Park and H. G. Park, Chem. Commun., 2015, 51, 13744 DOI: 10.1039/C5CC05010C

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