Issue 29, 2016
From the journal:

Chemical Communications

An enzyme-responsive controlled release system based on a dual-functional peptide†

X. Li,ab   S. Burger,a   A. J. O'Connor,a   L. Ong,abc   J. A. Karasbd  and  S. L. Gras*abc  

* Corresponding authors

a Particulate Fluids Processing Centre, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, VIC 3010, Australia
E-mail: s.gras@unimelb.edu.au

b The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC 3010, Australia

c The ARC Dairy Innovation Hub, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, VIC 3010, Australia

d The School of Chemistry, The University of Melbourne, Parkville, VIC 3010, Australia

Abstract

A new controlled release system was developed by loading a dual-functional peptide (DFP) on a mesoporous silica material. One-pot synthesis produced a DFP that was stimuli responsive, releasing a therapeutic peptide by protease cleavage. The design provides new steps towards smart biomaterials.

Graphical abstract: An enzyme-responsive controlled release system based on a dual-functional peptide

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Article information

DOI
https://doi.org/10.1039/C5CC10480G
Article type
Communication
Submitted
22 Dec 2015
Accepted
14 Mar 2016
First published
14 Mar 2016

Chem. Commun., 2016,52, 5112-5115

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An enzyme-responsive controlled release system based on a dual-functional peptide

X. Li, S. Burger, A. J. O'Connor, L. Ong, J. A. Karas and S. L. Gras, Chem. Commun., 2016, 52, 5112 DOI: 10.1039/C5CC10480G

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