Issue 6, 2016
From the journal:

Nanoscale

Intrinsic fluorescence of selenium nanoparticles for cellular imaging applications†

A. Khalid,*a   Phong A. Tran,*bc   Romina Norello,a   David A. Simpson,a   Andrea J. O'Connorb  and  Snjezana Tomljenovic-Hanic*a  

* Corresponding authors

a School of Physics, University of Melbourne, Parkville, VIC 3010, Australia

b Department of Chemical and Biomolecular Engineering, University of Melbourne, VIC 3010, Australia

c Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia
E-mail: asmak@student.unimelb.edu.au, phong.tran@qut.edu.au, snjezana.thanic@unimelb.edu.au

Abstract

Nanoparticles hold great potential in contributing to high-resolution bioimaging as well as for biomedical applications. Although, selenium (Se) nanoparticles (NPs) have been investigated owing to their potential roles in therapeutics, the imaging capability of these NPs has never been explored. This manuscript identifies the intrinsic fluorescence of Se NPs, which is highly beneficial for nanoscale imaging of biological structures. The emission of individual NPs and its evolution with time is explored. The photoluminescence spectra has revealed visible to near infrared emission for Se NPs. The work finally reflects on the role of this intrinsic fluorescence for in vitro imaging and tracking in fibroblast cells, without the need of any additional tags. This technique would overcome the limitations of the conventionally used methods of imaging with tagged fluorescent proteins and dyes, preventing possible adverse cellular effects or phototoxicity caused by the added fluorescent moieties.

Graphical abstract: Intrinsic fluorescence of selenium nanoparticles for cellular imaging applications

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Article information

DOI
https://doi.org/10.1039/C5NR08771F
Article type
Paper
Submitted
10 Dec 2015
Accepted
08 Jan 2016
First published
11 Jan 2016
This article is Open Access
Creative Commons BY license

Nanoscale, 2016,8, 3376-3385

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Intrinsic fluorescence of selenium nanoparticles for cellular imaging applications

A. Khalid, P. A. Tran, R. Norello, D. A. Simpson, A. J. O'Connor and S. Tomljenovic-Hanic, Nanoscale, 2016, 8, 3376 DOI: 10.1039/C5NR08771F

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