Issue 48, 2016
From the journal:

Organic & Biomolecular Chemistry

Macrolactam analogues of macrolide natural products

Helmut M. Hügel,*a   Andrew T. Smithb  and  Mark A. Rizzacasa*c  

* Corresponding authors

a School of Science & Biomedical and Health Innovations Enabling Capability Platform, RMIT University, GPO Box 2476, Melbourne, VIC 3001, Australia
E-mail: helmut.hugel@rmit.edu.au
Tel: +613 9925 2626

b Griffith Sciences, Gold Coast campus, Griffith University, QLD 4222, Australia

c School of Chemistry, the Bio21 Institute, The University of Melbourne, VIC 3010, Australia
E-mail: masr@unimelb.edu.au
Tel: +613 8344 2397

Abstract

The chemical modification of macrolide natural products into aza- or lactam analogues is a strategy employed to improve their metabolic stability and biological activity. The methods for the synthesis of several lactam analogues of macrolide natural products are highlighted and aspects of their biological properties presented.

Graphical abstract: Macrolactam analogues of macrolide natural products

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Article information

DOI
https://doi.org/10.1039/C6OB02149B
Article type
Review Article
Submitted
03 Oct 2016
Accepted
27 Oct 2016
First published
27 Oct 2016

Org. Biomol. Chem., 2016,14, 11301-11316

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Macrolactam analogues of macrolide natural products

H. M. Hügel, A. T. Smith and M. A. Rizzacasa, Org. Biomol. Chem., 2016, 14, 11301 DOI: 10.1039/C6OB02149B

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