Issue 68, 2017

Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation

Abstract

Aggregation of the highly amyloidogenic IAPP is endogenously inhibited inside beta-cell granules at millimolar concentrations. Combining in vitro experiments and computer simulations, we demonstrated that the stabilization of IAPP upon the formation of zinc-coordinated ion molecular complex with C-peptide might be important for the endogenous inhibition of IAPP aggregation.

Graphical abstract: Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation

Supplementary files

Article information

Article type
Communication
Submitted
02 Jun 2017
Accepted
19 Jul 2017
First published
19 Jul 2017

Chem. Commun., 2017,53, 9394-9397

Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation

X. Ge, A. Kakinen, E. N. Gurzov, W. Yang, L. Pang, E. H. Pilkington, P. Govindan-Nedumpully, P. Chen, F. Separovic, T. P. Davis, P. C. Ke and F. Ding, Chem. Commun., 2017, 53, 9394 DOI: 10.1039/C7CC04291D

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