Influence of a pH-sensitive polymer on the structure of monoolein cubosomes

Monika Kluzek; Arwen I. I. Tyler; Shiqi Wang; Rongjun Chen; Carlos M. Marques; Fabrice Thalmann; John M. Seddon; Marc Schmutz

doi:10.1039/C7SM01620D

Influence of a pH-sensitive polymer on the structure of monoolein cubosomes

Monika Kluzek,

*^a Arwen I. I. Tyler,

^bc Shiqi Wang,

^d Rongjun Chen,

^d Carlos M. Marques,

^a Fabrice Thalmann,

*^a John M. Seddon

^b and Marc Schmutz

Author affiliations

* Corresponding authors

^a Université de Strasbourg, CNRS, Institut Charles Sadron, UPR022, 23 rue du Loess, 67034 Strasbourg Cedex, France
E-mail: monika.kluzek@ics-cnrs.unistra.fr, fabrice.thalmann@ics-cnrs.unistra.fr

^b Department of Chemistry, Imperial College London, South Kensington Campus, London SW7 2AZ, UK

^c Food Colloids and Processing Group, School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK

^d Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK

Abstract

Cubosomes consist in submicron size particles of lipid bicontinuous cubic phases stabilized by surfactant polymers. They provide an appealing road towards the practical use of lipid cubic phases for pharmaceutical and cosmetic applications, and efforts are currently being made to control the encapsulation and release properties of these colloidal objects. We overcome in this work the lack of sensitivity of monoolein cubosomes to pH conditions by using a pH sensitive polymer designed to strongly interact with the lipid structure at low pH. Our cryo-transmission electron microscope (cryo-TEM) and small-angle X-ray scattering (SAXS) results show that in the presence of the polymer the cubic phase structure is preserved at neutral pH, albeit with a larger cell size. At pH 5.5, in the presence of the polymer, the nanostructure of the cubosome particles is significantly altered, providing a pathway to design pH-responsive cubosomes for applications in drug delivery.

Article information

https://doi.org/10.1039/C7SM01620D

Article type

Paper

Submitted

11 Aug 2017

Accepted

30 Sep 2017

First published

02 Oct 2017

Download Citation

Soft Matter, 2017,13, 7571-7577

Permissions

Request permissions

Influence of a pH-sensitive polymer on the structure of monoolein cubosomes

M. Kluzek, A. I. I. Tyler, S. Wang, R. Chen, C. M. Marques, F. Thalmann, J. M. Seddon and M. Schmutz, Soft Matter, 2017, 13, 7571 DOI: 10.1039/C7SM01620D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Soft Matter

Influence of a pH-sensitive polymer on the structure of monoolein cubosomes

Abstract

Article information

Download Citation

Permissions

Influence of a pH-sensitive polymer on the structure of monoolein cubosomes

Social activity

Search articles by author

Spotlight

Advertisements