Issue 23, 2018

A PCR-free technology to detect and quantify microRNAs directly from human plasma

Abstract

A novel sensitive, specific and rapid method for the detection and quantification of microRNAs without requiring extraction from their biological sources is now available using a novel chemical based, PCR-free technology for nucleic acid testing. In this study, we both demonstrate how this method can be used to profile miR-451a, an important miRNA in erythropoiesis, and compare with the gold standard RT-qPCR.

Graphical abstract: A PCR-free technology to detect and quantify microRNAs directly from human plasma

Supplementary files

Article information

Article type
Communication
Submitted
24 Jul 2018
Accepted
25 Sep 2018
First published
27 Sep 2018

Analyst, 2018,143, 5676-5682

A PCR-free technology to detect and quantify microRNAs directly from human plasma

A. Marín-Romero, A. Robles-Remacho, M. Tabraue-Chávez, B. López-Longarela, R. M. Sánchez-Martín, J. J. Guardia-Monteagudo, M. A. Fara, F. J. López-Delgado, S. Pernagallo and J. J. Díaz-Mochón, Analyst, 2018, 143, 5676 DOI: 10.1039/C8AN01397G

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