Issue 4, 2019
From the journal:

Food & Function

Re-examining the role of the gut microbiota in the conversion of the lipid-lowering statin monacolin K (lovastatin) into its active β-hydroxy acid metabolite

D. Beltrán,a   M. D. Frutos-Lisón,a   J. C. Espín ORCID logo a  and  R. García-Villalba ORCID logo *a  

* Corresponding authors

a Laboratory of Food & Health, Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, P.O. Box 164, 30100 Campus de Espinardo, Murcia, Spain
E-mail: rgvillalba@cebas.csic.es

Abstract

Monacolin K (MK, lovastatin), a naturally occurring statin, only exerts lipid-lowering effects in its active β-hydroxy acid form (MKA). This activation was thought to be mediated by the gut microbiota (GM). We report here for the first time that the GM does not convert MK into MKA (a spontaneous pH-dependent conversion) but catabolises MKA. The GM might hamper the lipid-lowering effects by degrading the active metabolite MKA.

Graphical abstract: Re-examining the role of the gut microbiota in the conversion of the lipid-lowering statin monacolin K (lovastatin) into its active β-hydroxy acid metabolite

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Article information

DOI
https://doi.org/10.1039/C8FO02594K
Article type
Communication
Submitted
28 Dec 2018
Accepted
02 Mar 2019
First published
12 Mar 2019
This article is Open Access
Creative Commons BY-NC license

Food Funct., 2019,10, 1787-1791

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Re-examining the role of the gut microbiota in the conversion of the lipid-lowering statin monacolin K (lovastatin) into its active β-hydroxy acid metabolite

D. Beltrán, M. D. Frutos-Lisón, J. C. Espín and R. García-Villalba, Food Funct., 2019, 10, 1787 DOI: 10.1039/C8FO02594K

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