Issue 25, 2018, Issue in Progress
From the journal:

RSC Advances

A short and efficient total synthesis of the bromotyrosine-derived alkaloid psammaplysene A†

Jingjing Xu, ORCID logo ab   Kai Wanga  and  Jinlong Wu ORCID logo *a  

* Corresponding authors

a Laboratory of Asymmetric Catalysis, Department of Chemistry, Zhejiang University, Hangzhou 310027, China
E-mail: wyz@zju.edu.cn

b Department of Chemistry, Hangzhou Medical College, Hangzhou 310053, China

Abstract

Psammaplysene A, an inhibitor of FOXO1a-mediated nuclear export, has been synthesized by a concise and improved route from tyrosine-derived acid and amine fragments which were easily constructed using commercially available p-hydroxybenzaldehyde and tyramine as starting material, respectively. The strategy provides an efficient access of psammaplysene analogues that can be explored for potential pharmaceutical or biological activities.

Graphical abstract: A short and efficient total synthesis of the bromotyrosine-derived alkaloid psammaplysene A

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Article information

DOI
https://doi.org/10.1039/C8RA02052C
Article type
Paper
Submitted
08 Mar 2018
Accepted
26 Mar 2018
First published
12 Apr 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 13747-13749

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A short and efficient total synthesis of the bromotyrosine-derived alkaloid psammaplysene A

J. Xu, K. Wang and J. Wu, RSC Adv., 2018, 8, 13747 DOI: 10.1039/C8RA02052C

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