Synthesis of remote fluoroalkylated alkenes by a palladium-catalyzed relay Heck-type reaction

Lixin Li; Zhengguang Zhao; Jing Xu; Haotian Luo; Yong Li; Xiantao Ma; Lin Tang; Bo Ren; Xinhua Cao; Yan-Na Ma

doi:10.1039/C9CC10048B

Synthesis of remote fluoroalkylated alkenes by a palladium-catalyzed relay Heck-type reaction†

Lixin Li,

*^a Zhengguang Zhao,^a Jing Xu,*^a Haotian Luo,^a Yong Li,^a Xiantao Ma,

^a Lin Tang,

^a Bo Ren,

^a Xinhua Cao

^a and Yan-Na Ma

^b

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* Corresponding authors

^a College of Chemistry and Chemical Engineering, Xinyang Normal University, Xinyang, Henan 464000, China
E-mail: lilixin@xynu.edu.cn, xujing@xynu.edu.cn

^b College of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China

Abstract

Herein, we report a palladium-catalyzed relay Heck-type reaction of fluoroalkyl bromide and terminal alkenes. The reaction involves fluoroalkylation of alkenes and migration of double bonds via a 1,5-hydrogen atom transfer strategy. Through this method, a series of remote fluoroalkylated alkenes was obtained under mild conditions.

Chemical Communications

Synthesis of remote fluoroalkylated alkenes by a palladium-catalyzed relay Heck-type reaction†

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Synthesis of remote fluoroalkylated alkenes by a palladium-catalyzed relay Heck-type reaction

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