Mastering bioactive coatings of metal oxide nanoparticles and surfaces through phosphonate dendrons

Dinh-Vu Nguyen; Ludivine Hugoni; Miriam Filippi; Francis Perton; Da Shi; Emilie Voirin; Laura Power; Geoffrey Cotin; Marie-Pierre Krafft; Arnaud Scherberich; Philippe Lavalle; Sylvie Begin-Colin; Delphine Felder-Flesch

doi:10.1039/C9NJ05565G

Mastering bioactive coatings of metal oxide nanoparticles and surfaces through phosphonate dendrons†

Dinh-Vu Nguyen,

^a Ludivine Hugoni,^b Miriam Filippi,^c Francis Perton,^a Da Shi,^d Emilie Voirin,^a Laura Power,^c Geoffrey Cotin,^a Marie-Pierre Krafft,

^d Arnaud Scherberich,^c Philippe Lavalle,

^b Sylvie Begin-Colin

^a and Delphine Felder-Flesch

*^a

Author affiliations

* Corresponding authors

^a Institut de Physique et de Chimie des Matériaux de Strasbourg IPCMS UMR CNRS UNISTRA 7504 23 rue du, Loess BP 43 67034 Strasbourg Cedex 2, France
E-mail: Delphine.Felder@ipcms.unistra.fr

^b INSERM UMR 1121, Biomaterials and Bioengineering Université de Strasbourg, 11 rue Humann, 67000 Strasbourg, France

^c Department of Biomedicine, University of Basel, University Hospital Basel, Hebelstrasse 20, Basel, Switzerland

^d University of Strasbourg Institut Charles Sadron (UPR 22, CNRS), 23 rue du Loess, 67034 Strasbourg Cedex, France

Abstract

We reported herein an efficient method for constructing dendritic bisphosphonic acid tweezers of generation 1 and 2, which have been proven as versatile surface coatings for metal oxides implants or nanoparticles. These dendritic structures were successfully utilized for different purposes: (i) biocompatible coverings for iron oxide nanoparticles through in vitro assays, (ii) antifouling surface coatings for silica through quartz crystal microbalance studies, and (iii) stabilizing ligands for magnetic nanoparticle–microbubble conjugates via preliminary Langmuir monolayer studies.

New Journal of Chemistry

Mastering bioactive coatings of metal oxide nanoparticles and surfaces through phosphonate dendrons†

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