Issue 12, 2020
From the journal:

RSC Advances

Amino acid sequences characterization and anti-inflammatory potency evaluation of Portulaca oleracea L. oligopeptides in macrophages

Shihui Chang,†a   Liping Wang,†a   Ting Zhang,a   Yan Nie,a   Ruijie Liua  and  Lihua Ma ORCID logo *a  

* Corresponding authors

a Dongying People's Hospital of Shandong, Shandong, China
E-mail: lhma_2019@163.com
Fax: +86-546-85531934
Tel: +86-546-85531934

Abstract

The Portulaca oleracea L. oligopeptides are seldom explored because they are often present in a complex matrix. In the current study, eleven novel Portulaca oleracea L. oligopeptides (POPs) were isolated and their mino acid sequence identified. Further, the anti-inflammatory potency was explored in lipopolysaccharide (LPS)-induced RAW264.7 cells. Results showed that POP-1∼[EHGEYE] possessed excellent anti-inflammatory potency by attenuating the pro-inflammatory cytokine expression (TNF-α, NO, IL-1β); inhibiting iNOS and COX-2 expressions and regulating the MAPK, PI3K/Akt and NF-κB signaling pathways. This may be an important molecular mechanism of POPs in anti-inflammatory damage.

Graphical abstract: Amino acid sequences characterization and anti-inflammatory potency evaluation of Portulaca oleracea L. oligopeptides in macrophages

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Article information

DOI
https://doi.org/10.1039/C9RA10465H
Article type
Paper
Submitted
12 Dec 2019
Accepted
31 Jan 2020
First published
19 Feb 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 7321-7327

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Amino acid sequences characterization and anti-inflammatory potency evaluation of Portulaca oleracea L. oligopeptides in macrophages

S. Chang, L. Wang, T. Zhang, Y. Nie, R. Liu and L. Ma, RSC Adv., 2020, 10, 7321 DOI: 10.1039/C9RA10465H

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